Glial amplification of synaptic signals

Glial Cells and Synaptic Plasticity

1Department of Psychology, Nanjing University of Chinese Medicine, Nanjing 210023, China 2Center of Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, NY 14643, USA 3Department of Neurosurgery, Baylor Scott & White Health, Temple, TX 76508, USA 4Department of Psychology, Nanjing Normal University, Nanjing, Jiangsu 210023, China 5Institute of Bioscience ...

NG2 glial cells integrate synaptic input in global and dendritic calcium signals

Synaptic signaling to NG2-expressing oligodendrocyte precursor cells (NG2 cells) could be key to rendering myelination of axons dependent on neuronal activity, but it has remained unclear whether NG2 glial cells integrate and respond to synaptic input. Here we show that NG2 cells perform linear integration of glutamatergic synaptic inputs and respond with increasing dendritic calcium elevations...

Editorial Glial Control of Synaptic Function

Our view of glial function has undergone dramatic changes in recent years. For much of the past century, glial cells were believed to have little influence on neuronal responses. Glia were thought to provide structural and metabolic support to neurons, but not to interact actively with them. Recent studies have demonstrated just how misleading was this classical view. Robust bidirectional commu...

Depression as a Glial-Based Synaptic Dysfunction

Recent studies combining pharmacological, behavioral, electrophysiological and molecular approaches indicate that depression results from maladaptive neuroplastic processes occurring in defined frontolimbic circuits responsible for emotional processing such as the prefrontal cortex, hippocampus, amygdala and ventral striatum. However, the exact mechanisms controlling synaptic plasticity that ar...

Modulation of Synaptic Amplification in Sympathetic Ganglia